Daclatasvir Dihydrochloride

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Pangalan ng API Indikasyon Pagtutukoy US DMF EU DMF CEP
Daclatasvir Dihydrochloride HCV In-House    


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Paglalarawan

Ang Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) ay isang malakas at aktibo sa bibigProtina ng HCV NS5Ainhibitor na mayEC50s saklaw ng 9-146 pM para samaramihang HCV replicon genotypes.Ang Daclatasvir dihydrochloride ay isa ringorganic anion transporting polypeptide 1B (OATP1B)atOATP1B3inhibitor na mayIC50s ng 1.5 µM at 3.27 µM, ayon sa pagkakabanggit.

IC50& Target

EC50: 50 pM (HCV replicon genotype 1a), 9 pM (HCV replicon genotype 1b), 71 pM (HCV replicon genotype 2a), 146 pM (HCV replicon genotype 3a), 12 pM (HCV replicon genotype 4a) at 33 pM HCV replicon genotype 5a)[1]
Kd: 8 nM (NS5A33-202) at 210 nM (NS5A26-202)[2]
IC50: 1.5 µM (OATP1B) at 3.27 µM (OATP1B3)[3]

Sa Vitro

Ang Daclatasvir (BMS-790052) ay nagpapakita ng makapangyarihang aktibidad ng pagbabawal sa lahat ng genotype na nasubok, na may EC50mga halaga mula 9 pM hanggang 146 pM.Pinipigilan ng Daclatasvir ang HCV replicon genotype 1a, 1b, 2a, 3a, 4a at 5a na may EC50mga halagang 50 pM, 9 pM, 71 pM, 146 pM, 12 pM at 33 pM, ayon sa pagkakabanggit.Ang Daclatasvir ay isang potent inhibitor ng JFH-1 genotype 2a infectious virus na nagrereplika sa cell culture (EC50=28 pM)[1].Ang Daclatasvir (BMS-790052) ay mahigpit na nagbubuklod sa NS5A33-202 at NS5A26-202 na may Kds ng 8 nM at 210 nM, ayon sa pagkakabanggit[2].

Imbakan

Pulbos

-20°C

3 taon
 

4°C

2 taon
Sa solvent

-80°C

6 na buwan
 

-20°C

1 buwan


Klinikal na Pagsubok

Numero ng NCT Sponsor Kundisyon Petsa ng Pagsisimula

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Phase 4

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Maagang Phase 1

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Phase 1

 

CERTIFICATE

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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