Doxycycline Hyclate
Background
Ang Doxycycline hyclate ay isang antibiotic [1].
Ang Doxycycline hyclate ay isang derivative ng tetracycline at nagtataglay ng mga aktibidad ng anti-inflammatory at antimicrobial.Pinipigilan ng Doxycycline ang pagtitiklop ng dengue virus sa vitro sa paraang nakadepende sa temperatura.Ang halaga ng IC50 ay 52.3μM sa 37°C at 26.7μM sa 40°C.Pinipigilan nito ang dengue virus sa pamamagitan ng pagpigil sa NS2B-NS3 serine protease ng virus.Binabawasan ng 60μM doxycycline ang CPE ng mga cell na nahawahan ng DNEV2 [1].
Ang Doxycycline ay natagpuan na isang inhibitor ng MMP.Ang paggamot sa doxycycline ay binabawasan ang mga antas ng MMP-8 at -9 at pinipigilan ang pagpapahayag ng tissue na MMP-2 at MMP-9.Bukod dito, ang paggamot na may doxycycline ay makabuluhang binabawasan ang saklaw ng intracranial aneurysms.Ang Doxycycline ay naiulat din na isang anti-inflammatory agent batay sa pagsugpo nito sa matrix metalloproteinases.Bilang karagdagan, ang doxycycline ay may makapangyarihang aktibidad na antimalarial na may halaga ng IC50 na 320nM sa 96h in vitro [2, 3].
Mga sanggunian:
[1] Rothan HA, Mohamed Z, Paydar M, Rahman NA, Yusof R. Inhibitory effect ng doxycycline laban sa dengue virus replication in vitro.Arko Virol.2014 Abr;159(4):711-8.
[2] Maradni A, Khoshnevisan A, Mousavi SH, Emamirazavi SH, Noruzijavidan A. Tungkulin ng matrix metalloproteinases (MMPs) at MMP inhibitors sa intracranial aneurysms: isang review na artikulo.Med J Islam Repub Iran.2013 Nob;27(4):249-254.
[3] Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML.In vitro at in vivo antimalarial efficacies ng optimized tetracyclines.Mga Ahente ng Antimicrob Chemother.2013 Hul;57(7):3131-6.
Paglalarawan
Ang Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), isang antibiotic, ay isang oral active at broad-spectrum metalloproteinase (MMP) inhibitor[1].
Klinikal na Pagsubok
Numero ng NCT | Sponsor | Kundisyon | Petsa ng Pagsisimula | Phase |
NCT00246324 | Louisiana State University Health Sciences Center Shreveport|Biogen | Multiple sclerosis | Disyembre 2003 | Phase 4 |
NCT00910715 | University Medical Center Ljubljana | Erythema Chronicum Migrans | Hunyo 2009 | Hindi maaari |
NCT00243893 | University of California, San Francisco|National Institute of Neurological Disorders and Stroke (NINDS) | Aneurysms|Mga Arteriovenous Malformation | Hulyo 2004 | Phase 1 |
NCT00126399 | CollaGenex Pharmaceuticals | Rosacea | Hunyo 2004 | Phase 3 |
NCT01318356 | Radboud University|ZonMw: The Netherlands Organization for Health Research and Development | Q Fever|Fatigue Syndrome, Chronic|Coxiella Infection | Abril 2011 | Phase 4 |
NCT00177333 | Unibersidad ng Pittsburgh | Aborsyon, Sapilitan|Pagsusuka | Setyembre 2005 | Phase 4 |
NCT00007735 | US Department of Veterans Affairs|Pfizer|United States Department of Defense|VA Office of Research and Development | Persian Gulf Syndrome|Mga Impeksyon sa Mycoplasma | Enero 1999 | Phase 3 |
NCT00351273 | University of South Florida|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Arthritis, Reactive|Reiter Disease | Mayo 2006 | Phase 3 |
NCT00469261 | Ospital ng Careggi | Myocardial Infarction|Pag-remodel ng Kaliwang Ventricular | Mayo 2007 | Phase 2 |
NCT00547170 | Unibersidad ng Pittsburgh|Tu Du Hospital | Endometritis | Enero 2007 | Phase 4 |
NCT01475708 | University Medical Center Ljubljana | Lyme Borreliosis | Mayo 2011 |
|
NCT01368341 | Morten Lindbaek|Norwegian Institute of Public Health|Sorlandet Hospital HF|Norwegian University of Life Sciences|University of Oslo | Erythema Migrans|Erythema Chronicum Migrans|Borreliosis|Lyme Disease|Maagang Lyme Disease | Hunyo 2011 | Phase 4 |
NCT02538224 | Unibersidad ng Islamikong Azad, Tehran | Talamak na Periodontitis | Hulyo 2013 | Phase 2|Phase 3 |
NCT00066027 | Unibersidad ng Nebraska|National Institute of Dental and Craniofacial Research (NIDCR) | Periodontitis | Hunyo 2002 | Phase 3 |
NCT00376493 | Hospital de Clinicas de Porto Alegre | Septic Abortion | Mayo 2006 | Phase 4 |
NCT03448731 | Fundacion CRIS de Investigación para sa Vencer el Cáncer|Amgen|Apices Soluciones SL | Pagkalason sa Balat | Mayo 10, 2018 | Phase 2 |
NCT00989742 | Unibersidad ng Nottingham | Lymphangioleiomyomatosis|Tuberous Sclerosis | Hulyo 2009 | Phase 4 |
NCT01438515 | Horizon Health Network | Methicillin-resistant Staphylococcus aureus | Agosto 2008 | Hindi maaari |
NCT02929121 | Ang Task Force for Global Health|United States Agency for International Development (USAID) | Lymphedema|Lymphatic Filariasis|Filariasis | Enero 15, 2019 | Phase 3 |
NCT00952861 | Odense University Hospital|Kolding Sygehus|Svendborg Hospital|Fredericia Hospital|Naestved Hospital|Hillerod Hospital, Denmark|Region Syddanmark|Danmarks Lungeforening|Danish National Research Foundation | Sakit sa Pulmonary, Talamak na Nakahahadlang | Oktubre 2009 | Phase 4 |
NCT00138801 | Ospital ng Sorlandet HF | Lyme Neuroborreliosis | Marso 2004 | Phase 3 |
NCT00942006 | University Medical Center Ljubljana | Pinaghihinalaang Maagang Lyme Neuroborreliosis | Hulyo 2009 | Hindi maaari |
NCT02713607 | Unibersidad ng California, Davis | Acne Vulgaris | Marso 2016 | Phase 1|Phase 2 |
NCT00560703 | Galderma | Blepharitis|Meibomianitis|Tuyong Mata | Nobyembre 2007 | Phase 2 |
NCT01014260 | Johns Hopkins University | Sakit sa Cardiovascular | Setyembre 2010 | Phase 4 |
NCT00000938 | National Institute of Allergy and Infectious Diseases (NIAID) | Sakit na Lyme | Phase 3 | |
NCT01398072 | University College, London|Royal Free Hampstead NHS Trust|University of Cambridge|National Institute for Health Research, United Kingdom | Chronic Obstructive Pulmonary Disease (COPD). | Disyembre 2011 | Phase 3 |
NCT03479502 | Vanderbilt University Medical Center|Orthopedic Research and Education Foundation | Adhesive Capsulitis|Adhesive Capsulitis ng Hindi Natukoy na Balikat|Frozen Shoulder | Enero 5, 2018 | Phase 4 |
NCT02929134 | Ang Task Force for Global Health|United States Agency for International Development (USAID) | Lymphedema|Lymphatic Filariasis|Filariasis | Pebrero 16, 2018 | Phase 3 |
NCT00480532 | Oregon Health and Science University | Mga Contraceptive, Oral | Mayo 2007 | Hindi maaari |
NCT01594827 | Johns Hopkins University|Case Western Reserve University|Cystic Fibrosis Foundation | Cystic fibrosis | Oktubre 2012 | Phase 2 |
NCT01744093 | Weill Medical College ng Cornell University|National Heart, Lung, and Blood Institute (NHLBI) | HIV|Chronic Obstructive Pulmonary Disease (COPD)|Emphysema | Hulyo 17, 2014 | Hindi maaari |
NCT03530319 | Ospital ng National Taiwan University | Pneumonia, Mycoplasma | Nobyembre 10, 2018 | Hindi maaari |
NCT04167085 | Unibersidad ng California, Los Angeles | Epistaxis | Disyembre 18, 2017 | Phase 4 |
NCT01411202 | Ottawa Hospital Research Institute | Malignant Pleural Effusion | Hunyo 2011 | Phase 2 |
NCT01474590 | Galderma | Acne | Nobyembre 2011 | Phase 3 |
NCT00649571 | Mylan Pharmaceuticals | Malusog | Hulyo 2005 | Phase 1 |
NCT02899000 | Galderma Laboratories, LP | Acne Vulgaris | Hulyo 29, 2016 | Phase 4 |
NCT00538967 | Leiden University Medical Center | Aortic Aneurysm, Tiyan | Mayo 2002 | Phase 2 |
NCT00439400 | Alacrity Biosciences, Inc. | Tuyong Mata | Pebrero 2007 | Phase 2 |
NCT00917553 | Thomas Gardner|Penn State University|Juvenile Diabetes Research Foundation|Milton S. Hershey Medical Center | Diabetic Retinopathy | Hulyo 2009 | Phase 2 |
NCT00495313 | CollaGenex Pharmaceuticals | Rosacea | Marso 2007 | Phase 4 |
NCT01855360 | Brigham at Women's Hospital | amyloidosis;Puso (Pagpapakita)|Senile Cardiac Amyloidosis | Hunyo 2013 | Phase 1|Phase 2 |
NCT00419848 | Shahid Beheshti University of Medical Sciences | Acne | Agosto 2006 | Phase 2 |
NCT03532464 | Ospital ng Unibersidad, Bordeaux|USC EA 3671 Ang mga impeksyon ay humahantong sa mycoplasmes at chlamydiae | Impeksyon ng Chlamydia Trachomatis|Impeksyon sa Puwerta|Impeksyon sa Puwit | Hulyo 1, 2018 | Phase 4 |
NCT02756403 | Medstar Health Research Institute|Society of Family Planning | First Trimester Abortion | Marso 2016 | Hindi maaari |
NCT00353158 | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|National Institutes of Health Clinical Center (CC) | Mga Healthy Volunteer|Mga Impeksyon sa Fungal|Mga Impeksyon sa Bakterya | Hulyo 11, 2006 | Phase 1 |
NCT01317433 | Institut Cancerologie de l'Ouest | Colorectal Cancer Metastatic|Toxicity sa Balat | Disyembre 2010 | Phase 3 |
NCT01658995 | Petra M. Casey|Mayo Clinic | Pagdurugo na nauugnay sa ESI | Setyembre 13, 2012 | Phase 3 |
NCT03968562 | State University of New York - Downstate Medical Center | Mga pantal | Mayo 15, 2019 | Phase 2 |
NCT02569437 | Icahn School of Medicine sa Mount Sinai | Polyp ng Nasal Sinus | Setyembre 2014 | Phase 2 |
NCT01198509 | NYU Langone Health|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|Memorial Sloan Kettering Cancer Center | Rheumatoid Arthritis|Psoriatic Arthritis|Periodontal Disease | Enero 2010 | Hindi maaari |
NCT01163994 | University Medical Center Ljubljana | Maramihang Erythema Migrans | Hunyo 2010 | Hindi maaari |
NCT02388477 | Milton S. Hershey Medical Center | Pinsala ng Rotator Cuff | Hindi maaari | |
NCT01010295 | International Extranodal Lymphoma Study Group (IELSG) | Non-Hodgkin Lymphoma | Setyembre 2006 | Phase 2 |
NCT00775918 | Ranbaxy Laboratories Limited|Ranbaxy Inc. | Malusog | Hunyo 2005 | Hindi maaari |
NCT04050540 | University of Washington|Kenya Medical Research Institute|Kenya National AIDS & STI Control Programme|University of California, San Francisco|National Institute of Allergy and Infectious Diseases (NIAID) | Mga Impeksyon sa HIV|HIV+AIDS|Impeksyon sa Neisseria Gonorrheae|Impeksyon ng Chlamydia Trachomatis|Impeksyon ng Syphilis | Pebrero 5, 2020 | Phase 4 |
NCT02562651 | Russian Academy of Medical Sciences | Mga Sakit sa Vascular|Mga Sakit sa Cardiovascular|Acute Myocardial Infarction | Pebrero 2014 | Phase 2|Phase 3 |
NCT00001101 | National Institute of Allergy and Infectious Diseases (NIAID) | Sakit na Lyme | Phase 3 | |
NCT00340691 | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) | Mansonella Perstans Infection|Mp Microfilaremia | Disyembre 6, 2004 | Phase 2 |
NCT01112059 | Unibersidad ng Alabama sa Birmingham|Cystic Fibrosis Foundation | Cystic fibrosis | Nobyembre 2008 | Hindi maaari |
NCT00652704 | Par Pharmaceutical, Inc.|Anapharm | Upang Matukoy ang Bioequivalence Sa ilalim ng mga Kundisyon ng Fed | Hulyo 1999 | Phase 1 |
NCT01783860 | Tehran University of Medical Sciences | Posterior Blepharitis | Enero 2013 | Phase 2 |
NCT02564471 | State University of New York - Upstate Medical University|Walter Reed Army Institute of Research (WRAIR)|Kansas State University | Rabies | Abril 2016 | Phase 4 |
NCT04206631 | Unibersidad ng Indonesia | Acne Vulgaris | Abril 1, 2015 | Phase 1 |
NCT03956446 | University Medical Center Ljubljana|University of Ljubljana School of Medicine, Slovenia | Tick Borne Encephalitis | Setyembre 1, 2014 | Hindi maaari |
NCT03960411 | Felix Chikita Fredy, MD|National Cardiovascular Center Harapan Kita Hospital Indonesia|Indonesia University | ST Elevation Myocardial Infarction|Anterior Wall Myocardial Infarction|Heart Failure|Remodeling, Ventricular | Mayo 25, 2019 | Phase 3 |
NCT00322465 | National Institute of Allergy and Infectious Diseases (NIAID) | Urethritis | Nobyembre 2006 | Phase 2 |
NCT01375491 | University of California, San Diego|Ruth L. Kirschstein National Research Service Award|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Center for Research Resources (NCRR) | Type 2 Diabetes|Obesity | Oktubre 2009 | Phase 4 |
NCT03478436 | Medikal na Unibersidad ng Vienna|Dr.Limitado ang Reddy's Laboratories | Rosacea | Hulyo 2016 | Phase 1 |
NCT01207739 | Radboud University|Sint Maartenskliniek|ZonMw: The Netherlands Organization for Health Research and Development | Lyme Disease|Borrelia Infection | Setyembre 2010 | Phase 4 |
NCT00939562 | Pfizer | Impeksyon sa Bakterya | Nobyembre 2008 | Phase 4 |
NCT03608774 | National Institute of Allergy and Infectious Diseases (NIAID) | Impeksyon sa Anal Chlamydia | Hunyo 26, 2018 | Phase 4 |
NCT02281643 | Kwame Nkrumah University of Science and Technology|University of Bonn|Heinrich-Heine University, Duesseldorf | Mansonella Perstans Infection|Buruli Ulcer|Tuberculosis|Co-infection | Oktubre 2014 | Phase 2 |
NCT00066066 | Ang Forsyth Institute|National Institute of Dental and Craniofacial Research (NIDCR) | Periodontitis|Mga Sakit sa Periodontitis | Hulyo 2003 | Phase 2 |
NCT01798225 | Medical University of South Carolina|National Center for Research Resources (NCRR) | Periodontal Disease|Type 2 Diabetes Mellitus | Disyembre 2007 | Phase 4 |
NCT00612573 | Warner Chilcott | Acne Vulgaris | Pebrero 2008 | Phase 2 |
NCT01631617 | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|National Institutes of Health Clinical Center (CC) | Eksema|Dermatitis|Mga Sakit sa Balat, Genetic|Dermatitis, Atopic|Mga Sakit sa Balat | Setyembre 18, 2012 | Phase 2 |
NCT03173053 | Radboud University|ZonMw: The Netherlands Organization for Health Research and Development|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|Aalborg University Hospital|Rigshospitalet, Denmark | Staphylococcus Aureus|Karamdaman sa Paggalaw | Pebrero 8, 2018 | Hindi maaari |
NCT00715858 | McMaster University|The Physicians' Services Incorporated Foundation | Sakit na Alzheimer | Mayo 2008 | Phase 3 |
NCT03584919 | University Medical Center Ljubljana | Erythema Chronicum Migrans | Hunyo 1, 2006 | Hindi maaari |
NCT01469585 | Unibersidad ng Hawaii|Charles Drew Unibersidad ng Medisina at Agham|Meharry Medical College | Pambihirang Pagdurugo | Nobyembre 2011 | Hindi maaari |
NCT02759120 | Weill Medical College of Cornell University|Duke Clinical Research Institute|University of Chicago|University of Washington|University of Pittsburgh|National Heart, Lung, and Blood Institute (NHLBI) | Idiopathic Pulmonary Fibrosis | Marso 22, 2017 | Phase 3 |
NCT02735837 | Amirhossein Farahmand|Islamic Azad University, Tehran | Diabetes Mellitus na May Sakit na Periodontal | Enero 2015 | Phase 2|Phase 3 |
NCT03655197 | Unibersidad ng California, Davis | Rosacea|Ocular Rosacea|Cutaneous Rosacea | Nobyembre 2, 2017 | Maagang Phase 1 |
NCT01188954 | Northwell Health | Seroma | Enero 2010 | Hindi maaari |
NCT00388778 | Shahid Beheshti University of Medical Sciences | Acne|Pamaga | Oktubre 2005 | Phase 2|Phase 3 |
NCT01087476 | Metropolitan Autonomous University|Instituto Nacional de Cancerologia de Mexico | Mucositis | Mayo 2010 | Phase 2 |
NCT02174757 | CD Pharma India Pvt.Ltd.|Sree Mookambika Institute of Dental Sciences | Talamak na Periodontitis | Agosto 2014 | Phase 3 |
NCT03911440 | Ospital ng National Taiwan University | Atypical Pneumonia | Nobyembre 10, 2018 | Hindi maaari |
NCT02553083 | Rabin Medical Center | Impeksyon sa Bakterya Dahil sa Helicobacter Pylori (H. Pylori) | Oktubre 22, 2015 | Phase 4 |
NCT04234945 | Ospital ng Pagtuturo sa Pamantasang Ahmadu Bello | Infertility, Babae|Pelvic Inflammatory Disease | Enero 13, 2020 | Hindi maaari |
NCT00892281 | Galderma Laboratories, LP | Rosacea | Abril 2009 | Phase 4 |
NCT02913118 | Qingfeng Pharmaceutical Group | Community Acquired Pneumonia | Hulyo 2016 | Phase 4 |
NCT04153604 | Methodist Health System | Cirrhosis|Spontaneous Bacterial Peritonitis | Nobyembre 4, 2019 |
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NCT03153267 | University Medical Center Ljubljana|University of Ljubljana School of Medicine, Slovenia | Erythema Chronicum Migrans | Hunyo 1, 2017 | Hindi maaari |
NCT03116659 | James J. Peters Veterans Affairs Medical Center | Lymphoma, T-Cell, Cutaneous | Pebrero 1, 2018 | Maagang Phase 1 |
NCT03401372 | Jian Li|Peking University First Hospital|Chinese PLA General Hospital|Beijing Chao Yang Hospital|West China Hospital Affiliated with Sichuan University|Tongji Hospital Affiliated with Tongji Medical College of HUST|Union Hospital Affiliated with Tongji Medical College of HUST|Shanghai Changzheng Hospital| Nanfang Hospital ng Southern Medical University|Peking Union Medical College Hospital | amyloidosis;Systemic | Abril 21, 2018 | Hindi maaari |
NCT01380496 | Par Pharmaceutical, Inc.|Anapharm | Upang Matukoy ang Bioequivalence Sa ilalim ng mga Kundisyon ng Fed | Nobyembre 1999 | Phase 1 |
NCT03083197 | Unibersidad ng Oxford|Shoklo Malaria Research Unit|Chiangrai Prachanukroh Hospital | Scrub Typhus | Oktubre 15, 2017 | Phase 4 |
NCT00237016 | Medical Corps, Israel Defense Force | Muling Lagnat, Tick-Borne|Jarisch Herxheimer Reaction | Abril 2002 | Phase 2|Phase 3 |
NCT01308619 | Galderma Laboratories, LP | Rosacea | Abril 2011 | Phase 4 |
NCT01198912 | Ospital ng Unibersidad, Ghent | Talamak na Rhinosinusitis|Nasal Polyps | Nobyembre 22, 2011 | Phase 2 |
NCT02016365 | Unibersidad ng Umeå | Transthyretin Amyloidosis|Cardiomyopathy | Pebrero 2012 | Phase 2 |
NCT00783523 | Unibersidad ng California, San Francisco | Arteriovenous Malformations|Cavernous Angiomas|Brain Aneurysms | Marso 2008 | Phase 1 |
NCT03337932 | University Medical Center Ljubljana | Erythema Chronicum Migrans | Enero 1, 2018 | Hindi maaari |
NCT00568711 | Dong-Min Kim|Chosun University Hospital | Scrub Typhus | Setyembre 2006 | Hindi maaari |
NCT01874860 | Unibersidad ng Louisville|James Graham Brown Cancer Center | Colorectal Cancer|Ulo at Leeg na Kanser | Agosto 2013 | Phase 2 |
NCT01171859 | IRCCS Policlinico S. Matteo | Transthyretin amyloidosis | Hulyo 2010 | Phase 2 |
NCT01653522 | Ang Cleveland Clinic | Mga Sakit sa Migraine|Sakit ng Ulo, Migraine|Migraine|Sakit ng Ulo|Migraine na May Aura|Migraine na Walang Aura|Mga Sakit sa Ulo, Pangunahin | Hulyo 2012 | Hindi maaari |
NCT01820910 | International Extranodal Lymphoma Study Group (IELSG) | Marginal Zone Lymphoma ng Ocular Adnexal | Marso 2013 | Phase 2 |
NCT01323101 | Unibersidad ng Timog California | Cystic fibrosis | Abril 2008 | Phase 4 |
NCT00829764 | Teva Pharmaceuticals USA | Malusog | Oktubre 2006 | Phase 1 |
NCT01668498 | AIO-Studien-gGmbH | Ras-wildtype Colorectal Cancer | Mayo 2011 | Phase 2 |
NCT01030666 | Peter Eickholz|Pamantasan ng Heidelberg|Dr.August Wolff GmbH & Co. KG Arzneimittel|Gaba International AG|Goethe University | Periodontitis | Abril 2007 | Phase 4 |
NCT00012688 | US Department of Veterans Affairs|Colgate-Periogard-Dentsply|VA Office of Research and Development | Diabetes Mellitus|Mahinang Glycemic Control|Peridontal Disease | Hindi maaari | |
NCT01885910 | Derm Research, PLLC|WFH MEDICAL, LLC | Acne Vulgaris | Hulyo 2013 | Phase 4 |
NCT02328469 | University Medical Center Ljubljana|Slovenian Research Agency|University of Ljubljana School of Medicine, Slovenia|Harvard University | Aseptic Meningitis | Hunyo 2014 |
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NCT00355602 | Unibersidad ng Dundee|Tenovus Scotland | Colitis, Ulcerative | Hulyo 2006 | Hindi maaari |
NCT02606032 | Hamilton Health Sciences Corporation|Hamilton Academic Health Sciences Organization | Ulcerative colitis | Mayo 2016 | Phase 2 |
NCT01465802 | Pfizer | Non Small Cell Lung Cancer (NSCLC) | Disyembre 26, 2011 | Phase 2 |
NCT02623959 | MD Anderson Cancer Center | Mga Advanced na Kanser|Malignant Pleural Effusions | Abril 27, 2016 | Phase 4 |
NCT03481972 | IRCCS Policlinico S. Matteo | TTR Cardiac Amyloidosis | Abril 11, 2018 | Phase 3 |
NCT00428818 | University of Texas Southwestern Medical Center | Impeksyon | Agosto 2005 | Hindi maaari |
NCT01935622 | Virginia Commonwealth University | Non-ischemic Cardiomyopathy|Systolic Heart Failure (NYHA II-III) | Hulyo 2012 | Phase 2 |
NCT01886560 | Unibersidad ng Sun Yat-sen | Nasusunog ang Mata | Setyembre 2013 | Phase 2|Phase 3 |
NCT04239755 | Pamantasan ng Damanhour|Pamantasan ng Tanta | Traumatikong Pinsala sa Utak | Disyembre 15, 2019 | Phase 4 |
NCT02204254 | Center Hospitalier Universitaire de Nice | Rosacea | Marso 2014 | Hindi maaari |
NCT00837213 | Stiefel, isang GSK Company|GlaxoSmithKline | Acne | Agosto 2007 | Phase 4 |
NCT03115177 | Rush University Medical Center | Osteoarthritis | Nobyembre 2015 | Hindi maaari |
NCT03618108 | Cadrock Pty. Ltd.|Center for Digestive Diseases, Australia | Coronary Heart Disease|Mga Impeksyon ng Chlamydophila Pneumoniae | Abril 4, 2018 | Phase 2 |
NCT03435952 | MD Anderson Cancer Center|BioMed Valley Discoveries, Inc|Merck Sharp & Dohme Corp. | Malignant Neoplasm of Breast|Malignant Neoplasms of Digestive Organs|Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System|Malignant Neoplasms of Female Genital Organs|Malignant Neoplasms of Ill-defined Secondary and Unspecified Sites|Malignant Neoplasms of Independent (Primas of Independent) Sites|Malignant Neoplasms of Lip Oral Cavity and Pharynx|Malignant Neoplasms of Male Genital Organs|Malignant Neoplasms of Mesothelial at Soft Tissue|Malignant Neoplasms of Respiratory and Intrathoracic Organs|Malignant Neoplasms of Thyroid and Other Endocrine Neplasms Tracts | Hulyo 10, 2018 | Phase 1 |
NCT01867294 | Academic and Community Cancer Research United|National Cancer Institute (NCI) | Advanced Malignant Neoplasm|Dermatologic Complication | Agosto 31, 2012 | Phase 2 |
NCT01677286 | Boston University | Amyloidosis | Hulyo 2012 | Phase 2 |
NCT00511875 | Thomas Gardner|Juvenile Diabetes Research Foundation|Milton S. Hershey Medical Center | Diabetic Retinopathy | Hulyo 2008 | Phase 2 |
NCT04108897 | Johns Hopkins University | Rosacea | Setyembre 17, 2019 | Maagang Phase 1 |
NCT00631501 | Kaunas University of Medicine|University Hospital, Linkoeping | Lateral Epicondylalgia (Tennis Elbow) | Hindi maaari | |
NCT02203682 | Unibersidad ng Sun Yat-sen | Graves Ophthalmopathy|Graves Disease|Mga Sakit sa Mata|Mga Sakit sa Thyroid|Mga Sakit sa Endocrine System|Mga Sakit sa Mata, Namamana|Hyperthyroidism|Mga Sakit sa Autoimmune|Mga Sakit sa Immune System | Hulyo 2014 | Phase 2 |
NCT02005653 | Indian Council of Medical Research | Filarial;Infestation | Pebrero 2009 | Phase 4 |
NCT03585140 | Centro Dermatológico Dr. Ladislao de la Pascua | Acne Vulgaris|Pagbabago sa Diyeta | Enero 1, 2016 | Hindi maaari |
NCT02147262 | University Medical Center Ljubljana|University of Ljubljana School of Medicine, Slovenia|Medical University of Vienna|Harvard University | Talamak na Atrophic Acrodermatitis | Hulyo 2013 | Hindi maaari |
NCT02220751 | Unibersidad ng Sao Paulo|Fundação de Amparo à Pesquisa do Estado de São Paulo | Periodontitis|Type 2 Diabetes Mellitus | Marso 2009 | Phase 3 |
NCT01825408 | Unibersidad ng North Carolina, Chapel Hill | Sinusitis | Pebrero 2013 | Phase 4 |
NCT02884713 | King Faisal Specialist Hospital at Research Center | GASTRITIS | Hunyo 2013 | Hindi maaari |
NCT02726646 | Unibersidad ng Campinas, Brazil|Pontificia Universidade Catolica de Sao Paulo | Talamak na Periodontitis | Hunyo 2015 | Phase 2 |
NCT00883818 | Samsung Medical Center | Overactive na pantog | Enero 2007 | Phase 4 |
NCT00829790 | Teva Pharmaceuticals USA | Malusog | Oktubre 2006 | Phase 1 |
NCT01949233 | University of Oxford|Oxford University Hospitals NHS Trust | Marfan Syndrome | Oktubre 2013 | Phase 2 |
NCT01518192 | University Medical Center Ljubljana|Slovenian Research Agency | Erythema Migrans|Mga Sintomas ng Post-Lyme Disease | Hunyo 2006 | Phase 4 |
NCT02845024 | Unibersidad ng Islamikong Azad, Tehran | Diabetes Mellitus na May Sakit na Periodontal | Setyembre 2014 | Hindi maaari |
NCT01879930 | University Hospital Inselspital, Berne | Talamak na Pelvic Pain Syndrome|Bladder Pain Syndrome | Nobyembre 2012 | Phase 4 |
NCT00041977 | CollaGenex Pharmaceuticals | Acne Rosacea | Hunyo 2002 | Phase 3 |
NCT02341209 | Rochester General Hospital | Cutaneous T-cell Lymphoma|Mycosis Fungoides|Sezary Syndrome | Pebrero 6, 2018 | Phase 2 |
NCT00002872 | Eastern Cooperative Oncology Group|National Cancer Institute (NCI)|North Central Cancer Treatment Group | Metastatic na Kanser | Nobyembre 1996 | Phase 3 |
NCT03162497 | Medikal na Unibersidad ng Vienna | Mga Dry Eye Syndrome|Meibomian Gland Dysfunction | Enero 8, 2018 | Phase 4 |
NCT01418742 | Gesellschaft fur Medizinische Innovation ?Hamatologie und Onkologie mbH|ClinAssess GmbH | Colorectal Carcinoma | Agosto 2011 | Phase 2 |
NCT00980148 | National Institute of Allergy and Infectious Diseases (NIAID) | Impeksyon ng Chlamydial | Disyembre 2009 | Phase 3 |
NCT03342456 | Ang Ikatlong Ospital ng Xiangya ng Central South University|Livzon Pharmaceutical Group Inc.|Yung Shin Pharm.Ind. Co., Ltd. | Duodenal Ulcer Dahil sa Helicobacter Pylori | Disyembre 13, 2017 | Phase 4 |
NCT04310930 | The University of Queensland|Australian Government Department of Health|Children's Hospital Foundation|Cystic Fibrosis Foundation|Newcastle University|Griffith University|Erasmus Medical Center|Monash University|University of Copenhagen|Hôpital Cochin|South Australian Health and Medical Research Institute|University ng Melbourne|James Cook University, Queensland, Australia|Murdoch Childrens Research Institute | Sakit sa Pulmonary Dahil sa Mycobacteria (Diagnosis) | Marso 2020 | Phase 2|Phase 3 |
NCT03709459 | Kirby Institute|South Australian Health and Medical Research Institute|Monash University | Pag-iwas sa STI | Disyembre 17, 2019 |
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NCT04067011 | Emergent BioSolutions|Biomedical Advanced Research and Development Authority | Anthrax | Agosto 12, 2019 | Phase 2 |
NCT02844634 | British Columbia Center para sa Pagkontrol ng Sakit | HIV|Syphilis | Mayo 15, 2018 | Phase 4 |
NCT00647959 | Mylan Pharmaceuticals | Malusog | Marso 2006 | Phase 1 |
NCT00170222 | Medical Center Alkmaar | Chronic obstructive pulmonary disease | Hulyo 2002 | Phase 4 |
NCT03075891 | Galderma | Rosacea | Hulyo 5, 2017 | Phase 4 |
NCT00031499 | National Institute of Allergy and Infectious Diseases (NIAID) | Syphilis | Hunyo 2000 | Phase 3 |
NCT01205464 | Unibersidad ng Linkoeping | Pagkapagod|Radicular Pain|Cognitive Dysfunction|Paresthesia|Paresis | Pebrero 2005 | Hindi maaari |
NCT01301586 | Nexgen Dermatologics, Inc. | ACNE VULGARIS | Nobyembre 2010 | Phase 1|Phase 2 |
NCT02305940 | Imperial College London | Chronic Obstructive Pulmonary Disease (COPD) | Hulyo 2014 | Phase 3 |
NCT00351182 | Dong-Min Kim|Chosun University Hospital | Scrub Typhus | Setyembre 2005 | Phase 3 |
NCT03334682 | Ospital ng Pamantasan ng Nantes | Acne Vulgaris | Enero 31, 2018 | Phase 3 |
NCT01788215 | Unibersidad ng Rochester | Polycystic Ovarian Syndrome (PCOS)|Irregular Menstrual Cycles|Androgen Excess | Nobyembre 2010 | Phase 3 |
NCT03076281 | Sidney Kimmel Cancer Center sa Thomas Jefferson University|Thomas Jefferson University | Larynx|LIP|Oral Cavity|Pharynx | Abril 3, 2017 | Phase 2 |
NCT00439166 | Hamilton Health Sciences Corporation|The Physicians' Services Incorporated Foundation|McMaster University | Sakit na Alzheimer | Pebrero 2007 | Phase 3 |
NCT02463942 | University Medical Center Ljubljana|University of Ljubljana School of Medicine, Slovenia | Tick-borne Encephalitis | Setyembre 2014 | Hindi maaari |
NCT00803842 | Northwestern University | Hindi Maliit na Cell Lung Cancer | Oktubre 2008 | Hindi maaari |
NCT02086591 | Unibersidad ng Rochester | Adult Diffuse Large B-Cell Lymphoma|Paulit-ulit na Mantle Cell Lymphoma|Lymphoma, Follicular|Marginal Zone B-Cell Lymphoma|Malignant Lymphoma - Lymphoplasmacytic|Waldenstrom Macroglobulinemia|Small Lymphocytic Lymphoma|Chronic Lymphocytic Lymphoma-CLLocytic Leukemia | Marso 2014 | Phase 2 |
NCT03980223 | University of California, San Francisco|University of Washington|National Institute of Allergy and Infectious Diseases (NIAID)|Mayne Pharma International Pty Ltd|San Francisco Department of Public Health | Gonorrhea|Chlamydia|Syphilis | Nobyembre 26, 2019 | Phase 4 |
NCT00355459 | University of Texas Southwestern Medical Center | Dry Eye Syndrome | Agosto 2005 | Hindi maaari |
NCT01254799 | Omar Mamdouh Shaaban|Assiut University | Pagdurugo ng Uterine | Enero 2008 | Phase 3 |
NCT01547325 | NanoSHIFT LLC|Departamento ng Depensa ng Estados Unidos | Dehisced Surgical Wounds | Mayo 2012 | Hindi maaari |
NCT00653380 | Par Pharmaceutical, Inc.|Anapharm | Upang Matukoy ang Bioequivalence sa ilalim ng mga Kondisyon ng Pag-aayuno | Setyembre 1999 | Phase 1 |
NCT00635609 | Warner Chilcott | Acne Vulgaris | Marso 2008 | Phase 4 |
NCT03765931 | Institut de Recherche pour le Development | Lagnat | Hulyo 2016 | Phase 4 |
NCT01160640 | Harold Wiesenfeld|National Institute of Allergy and Infectious Diseases (NIAID)|University of Pittsburgh | Pelvic Inflammatory Disease | Nobyembre 2010 | Phase 2 |
NCT01756833 | Unibersidad ng Maryland, Baltimore|National Institute on Aging (NIA) | Aneurysm | Mayo 2013 | Phase 2 |
NCT00688064 | Galderma | Malubhang Acne Vulgaris | Agosto 2008 | Phase 3 |
NCT01320033 | Galderma | Acne Vulgaris | Marso 29, 2011 | Phase 2 |
NCT03397004 | St. Michael's Hospital, Toronto|Barrow Neurological Institute|Duke University|Feinstein Institute for Medical Research|University of Pittsburgh|Sunnybrook Health Sciences Center | Hereditary Hemorrhagic Telangiectasia (HHT) | Setyembre 12, 2018 | Phase 2 |
NCT01635530 | Turku University Hospital | Lyme Neuroborreliosis | Agosto 2012 | Phase 4 |
NCT03727620 | Unibersidad ng Mohammed V Souissi | Agresibong Periodontitis | Enero 6, 2014 | Phase 1|Phase 2 |
NCT02688738 | Rothman Institute Orthopedics | Propionibacterium | Marso 2015 | Hindi maaari |
NCT00358462 | Unibersidad ng Washington|National Institute of Allergy and Infectious Diseases (NIAID) | Urethritis | Enero 2007 | Phase 3 |
NCT02864550 | British Columbia Center para sa Pagkontrol ng Sakit | Syphilis|Mga Impeksyon na Naililipat sa Sekswal | Agosto 15, 2019 | Phase 4 |
NCT01595594 | Unibersidad ng Sao Paulo|Fundação de Amparo à Pesquisa do Estado de São Paulo | Periodontal Disease|Type 2 Diabetes | Marso 2010 | Phase 3 |
NCT00964834 | PharmAthene, Inc.|National Institutes of Health (NIH)|Medarex|Quintiles, Inc.|Department of Health at Human Services | Anthrax | Hulyo 2009 | Phase 1 |
NCT01809444 | Unibersidad ng Sun Yat-sen | Mga Opthalmopathies na Kaugnay ng Thyroid | Nobyembre 2012 | Phase 2|Phase 3 |
NCT01590082 | MD Anderson Cancer Center|National Institutes of Health (NIH)|National Cancer Institute (NCI) | Melanoma | Nobyembre 2012 | Phase 1|Phase 2 |
NCT00207584 | Mga Sentro para sa Pagkontrol at Pag-iwas sa Sakit | Mycoplasma Pneumoniae | Enero 1994 | Hindi maaari |
NCT00775177 | Ranbaxy Laboratories Limited|Ranbaxy Inc. | Malusog | Hunyo 2005 | Hindi maaari |
NCT03462329 | University Medical Center Ljubljana | Erythema Migrans | Hunyo 1, 2018 | Hindi maaari |
NCT00000403 | Indiana University|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|National Institute on Aging (NIA) | Osteoarthritis | Setyembre 1996 | Phase 3 |
NCT03508232 | Unibersidad ng Alberta|Royal Alexandra Hospital | ST Segment Elevation Myocardial Infarction|Pagkabigo sa Puso | Enero 6, 2020 | Phase 2 |
NCT02553473 | Ospital ng Sorlandet HF | Neuroborreliosis, Borrelia Burgdorferi | Oktubre 2015 | Phase 3 |
NCT02207556 | Kolehiyo ng Medikal ng Wisconsin | Pangunahing Systemic Amyloidosis | Oktubre 1, 2014 | Phase 2 |
NCT01783106 | Royal Liverpool University Hospital|National Association for Colitis and Crohn's Disease|National Institute for Health Research, United Kingdom | Sakit ni Crohn | Pebrero 1, 2014 | Phase 2 |
NCT00353743 | Hospital de Clinicas de Porto Alegre | Aborsyon, Septic | Mayo 2006 | Hindi maaari |
NCT01727973 | Unibersidad ng Sun Yat-sen | Graves Ophthalmopathy|Graves Disease|Mga Sakit sa Mata|Mga Sakit sa Thyroid|Mga Sakit sa Endocrine System|Mga Sakit sa Mata, Namamana|Hyperthyroidism|Mga Sakit sa Autoimmune|Mga Sakit sa Immune System | Oktubre 2012 | Phase 1|Phase 2 |
NCT00857038 | Medical Center Alkmaar|Leiden University Medical Center|University of Amsterdam | Talamak na Obstructive Pulmonary Disease|Pamamamaga|Pulmonary Emphysema | Abril 2009 | Phase 4 |
NCT02774993 | National University Hospital, Singapore|Tan Tock Seng Hospital|National University, Singapore|A*Star | Tuberkulosis | Setyembre 2015 | Phase 2 |
NCT03474458 | IRCCS Policlinico S. Matteo | Cardiac AL Amyloidosis | Pebrero 11, 2019 | Phase 2|Phase 3 |
NCT02874430 | Sidney Kimmel Cancer Center sa Thomas Jefferson University|Thomas Jefferson University | Breast Carcinoma|Endometrial Clear Cell Adenocarcinoma|Endometrial Serous Adenocarcinoma|Uterine Corpus Cancer|Uterine Corpus Carcinosarcoma | Hunyo 8, 2016 | Phase 2 |
NCT00016835 | Unibersidad ng Michigan|National Institute of Dental and Craniofacial Research (NIDCR) | Sakit sa Periodontal|Diabetes Mellitus, Type 2 | Oktubre 17, 2001 | Phase 2 |
NCT00064766 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Pagdurugo ng Endometrial|Periodontal Disease | Pebrero 2003 | Phase 4 |
NCT00803452 | Unibersidad ng Louisville | Blepharitis | Hulyo 2008 | Phase 4 |
NCT01434173 | Bayer|RTI Health Solutions | Pinsala sa Atay na Dahil sa Droga | Hulyo 2001 |
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NCT00126204 | Barnes-Jewish Hospital | Aortic Aneurysm | Marso 2004 | Hindi maaari |
NCT01917721 | Hawaii Pacific Health | Sakit sa Kawasaki|Coronary Aneurysm | Oktubre 2013 | Phase 2 |
NCT02775695 | Kolehiyo ng Medikal ng Wisconsin | Resectable Pancreatic Cancer | Abril 3, 2017 | Phase 2 |
NCT03824340 | Ospital ng Aljazeera | kawalan ng katabaan | Enero 30, 2019 | Hindi maaari |
NCT01847976 | Ottawa Hospital Research Institute|Canadian Breast Cancer Foundation | Sakit | Agosto 2013 | Phase 2 |
NCT02850913 | Makerere University|University of Oxford | Mga seizure | Setyembre 5, 2016 | Phase 2 |
NCT00764361 | NanoSHIFT LLC | Ulcer sa Paa ng Diabetic | Enero 2009 | Phase 2 |
NCT02036528 | Royer Biomedical, Inc. | Mga Ulser sa Paa ng Diabetic | Enero 2014 | Phase 1|Phase 2 |
NCT01661985 | Ostergotland County Council, Sweden|Statens Serum Institut | Urethritis|Cervicitis|Genital Mycoplasma Infection|Chlamydia Trachomatis | Pebrero 2010 | Phase 4 |
NCT01380483 | Par Pharmaceutical, Inc.|Anapharm | Upang Matukoy ang Bioequivalence sa ilalim ng mga Kondisyon ng Pag-aayuno | Enero 2000 | Phase 1 |
NCT00648180 | Mylan Pharmaceuticals | Malusog | Hulyo 2005 | Phase 1 |
NCT01426269 | Galderma Laboratories, LP | Rosacea | Setyembre 2011 | Phase 4 |
NCT02753426 | Unibersidad ng California, San Francisco | Talamak na Sakit sa Bato|Cardiorenal Syndrome | Abril 2016 | Phase 1 |
NCT02583282 | Postgraduate Institute ng Medikal na Edukasyon at Pananaliksik | Malignant Pleural Effusion | Agosto 1, 2015 | Hindi maaari |
NCT02927496 | Ang Task Force for Global Health|United States Agency for International Development (USAID) | Lymphedema|Lymphatic Filariasis|Filariasis | Hunyo 19, 2018 | Phase 3 |
NCT00652795 | Par Pharmaceutical, Inc.|Anapharm | Upang Matukoy ang Bioequivalence sa ilalim ng mga Kondisyon ng Pag-aayuno | Hulyo 2004 | Phase 1 |
NCT03956212 | University Medical Center Ljubljana|University of Ljubljana School of Medicine, Slovenia | Erythema Migrans | Hunyo 1, 2017 | Hindi maaari |
NCT00855595 | Bayer | Papulopustular Rosacea | Pebrero 2009 | Phase 4 |
NCT03457636 | Derm Research, PLLC | Acne | Marso 19, 2018 | Phase 4 |
NCT02894268 | Sir Run Run Shaw Hospital | Impeksyon ng Helicobacter Pylori | Pebrero 2016 | Phase 4 |
NCT03465774 | MD Anderson Cancer Center|National Cancer Institute (NCI) | Malignant Pleural Effusion | Marso 8, 2018 | Maagang Phase 1 |
Kemikal na istraktura
Panukala18Mga proyekto sa Pagsusuri ng Pagkakaayon ng Kalidad na naaprubahan4, at6ang mga proyekto ay nasa ilalim ng pag-apruba.
Ang advanced na internasyonal na sistema ng pamamahala ng kalidad ay naglatag ng matatag na pundasyon para sa mga benta.
Ang pagsubaybay sa kalidad ay tumatakbo sa buong ikot ng buhay ng produkto upang matiyak ang kalidad at therapeutic effect.
Sinusuportahan ng pangkat ng Professional Regulatory Affairs ang mga hinihingi sa kalidad sa panahon ng aplikasyon at pagpaparehistro.